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A 4 page overview of the relation of drug ionization, specifically of whether the drug is a weak acid or a weak base, to its absorption into the body and consequent excretion from the body. Notes a differential absorption and excretion, according to physiological pH, as to where the drug is absorbed and when it is excreted. Bibliography lists 3 sources.
4 pages (~225 words per page)
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according to physiological pH, as to where the drug is absorbed and when it is excreted. Bibliography lists 3 sources. PPdrugCh.rtf Drug Chemistry:
The Effect of Ionization of Absorption and Excretion by - 15 Nov 2001 paper properly!
Most drugs are either weak bases or
weak acids. This chemical composition has a direct effect on the way that they are absorbed into the human body and excreted from that body. Some drugs, electrolytes,
are always ionized (Vincenzi, 2001). Others such as many of the natural steroids are always non-ionized (Vincenzi, 2001). Most, however are weak electrolytes, such as weak acids and
bases that can be either ionized or unionized (Vincenzi, 2001). This relationship is directly dependent on the pH (Vincenzi, 2001). It is a relationship which directly impacts the
ability of the drug to cross the bodys membranes and thus the rate which it enters the system and the time that it is retained in the system prior to
being excreted. Unionized forms of weak electrolytes cross membranes more readily, i.e. they have a higher permeability coefficient, because they are more lipid soluble (Vincenzi, 2001).
Acidic drugs can be characterized in part by -COOH, -SO3H, and phenols (Vincenzi, 2001). An example of an acidic drug is potassium penicillin G., a
drug which like others of its class is often available in the form of an alkali metal salt to facilitate its administration (Vincenzi, 2001). Acids of course become proton