Sample Essay on:
Valium Toxicity

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Essay / Research Paper Abstract

An 8 page discussion of the toxicity of valium (diazepam, which is a benzodiazepine. The writer discusses its history, epidemiology, pharmacology and toxicity. This paper includes an outline, which is a little over 1 page. Bibliography lists 4 sources.

Page Count:

8 pages (~225 words per page)

File: D0_khvalium.rtf

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Unformatted sample text from the term paper:

overview of its properties, as well as the dangers of toxicity, which is complicated by the fact that Diazepam tends to build up and be retained by the body. I. Background. a. History i. Discovered by Sternbach of Hoffman-La Roche and approved in 1963. ii. Improvement over barbiturates. b. Epidemiology II. Pharmacology a. Diazepam is a benzodiazepine. i. Influences neurosteroid metabolism and progesterone levels. ii. Affects the GABAa receptor. III. Pharmakinetics/Toxicokinetics a. Diazepam can be administered via oral, intravenous, inter-muscular, or by suppository. b. List side effects and signs of toxicity. IV. Diagnosis/testing for toxicity. a. Toxicity research with mice has shown that diazepam has shown that it produces levels of toxicity that produces sperm abnormalities. V. Management/treatment of toxicity. a. Antidote for overdose is flulmazine, which is used to treat severe respiratory depression and/or cardiovascular complications. Conclusions. Valium Toxicity Valium is generically known as diazepam, and it is typically referred to by this name in scholarly literature. The following discussion of diazepam offers a comprehensive overview of its properties, as well as the dangers of toxicity, which is complicated by the fact that Diazepam tends to build up and be retained by the body. Development of Valium History: Valium was discovered by Sternbach of Hoffman La Roche Pharmaceutical--more or less by chance (Ashton, 2005). The original compound was determined to have "hypnotic, anxiolytic and muscle relaxant effects" (Ashton, 2005). It was approved for sale in the U.S. in 1957 under the brand name of Valium. In the 1970s, Valium (diazepam) was the most widely prescribed drug in America (Breggin, 2008). By 1983, there were 17 benzodiazepines on the market, earning close to $3 billon in global sales and today, this category of ...

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